If concomitant use is warranted, carefully observe the client, significantly during therapy initiation and dose adjustment. Discontinue DILAUDID INJECTION if serotonin syndrome is suspected.
The hydromorphone in DILAUDID INJECTION may perhaps increase the frequency of seizures in people with seizure disorders and could increase the chance of seizures taking place in other scientific configurations associated with seizures.
When this medication is used to get a long time, it may well not work too. Converse with your medical doctor if this medication stops working perfectly.
Observe that this isn't an entire list of drug interactions. Other drug interactions could happen with Dilaudid or oxycodone.
Verify the solution bundle for Directions on how to keep your brand, or talk to your pharmacist. Maintain all medications absent from young children and Animals. See also Warning section.
Physical dependence is actually a state that develops as a result of a physiological adaptation in response to recurring drug use, manifested by withdrawal signals and symptoms after abrupt discontinuation or possibly a significant dose reduction of the drug.
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Hydromorphone is manufactured from morphine by way of catalytic hydrogenation and also is generated in trace amounts by human and other mammalian metabolisms of morphine.
The subsequent adverse reactions linked with the use of hydromorphone were being determined in medical research or postmarketing experiences.
Respiratory depression is definitely the chief threat for elderly sufferers dealt with with opioids, and it has happened after big Preliminary doses ended up administered to people who weren't opioid-tolerant or when opioids were co-administered with other agents that depress respiration.
[12] Owing to the possibility profile, the prescription and administration with the drug demand meticulous focus, along with an extensive understanding of its potential adverse effects and interactions.
Neonatal withdrawal syndrome can manifest in newborns of mothers who have already been making use of hydromorphone chronically. To mitigate this threat, it can be highly recommended to refrain from prolonged hydromorphone remedy during pregnancy.
DILAUDID INJECTION may very well be given intravenously, however the injection ought to be given extremely gradually. Fast intravenous injection of opioid analgesics increases the potential of side effects like hypotension and respiratory depression [see DOSAGE AND ADMINISTRATION].
Detect appropriate indications for hydromorphone therapy and its usage based over a affected individual's pain management needs and medical presentation.